D21S11

CODIS Core

D21S11 is a tetranucleotide short tandem repeat (STR) locus on chromosome 21 (21q21.1), one of the 20 CODIS core loci.

Basic Information

Chromosome

Cytogenetic Location

21q21.1

STRNaming template (FSSG)

TCTA[n]TCTG[n]TCTA[n]TATC[n]A[1]TCTA[2]TCCA[1]TATC[n]

Type

Tetranucleotide

Reference Allele

Explore internal sequence structure

See how the STRNaming name of the reference allele maps onto its sequence: repeat blocks, flanking regions and flanking variants.

Open STR Motif Explorer

See the reads at this locus

Open the built-in IGV viewer on the hg38 window of this marker with a 1000 Genomes sample.

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Genomic Coordinates

GRCh38/hg38

Repeat region

chr21:19,181,973-19,182,099 (127 bp)

GRCh37/hg19

Repeat region

chr21:20,554,291-20,554,417 (127 bp)

Motif and sequences are shown on the forward (+) strand of GRCh38.

Sequence structure (FSSG)

ISFG minimum range, bracketing and kit coverage from the Forensic Sequence Structure Guide, FSSG v6.1 (STRidER; distributed as FSSG_v6-1_beta.xlsx).

STRNaming Formatted ISFG Minimum Range for Common Alleles (FSSG)

TCTA[n]TCTG[n]TCTA[n]TATC[n]A[1]TCTA[2]TCCA[1]TATC[n]

TCTA[n]TCTG[n]TCTA[n]TATC[n]ATC[1]TATC[2]CATA[1]TCTA[n]TATC[2]

TCTA[5]TCTG[6]TCTA[3]TATC[4]A[1]TCTA[2]TCCA[1]TATC[n]A[1]TCTA[3]TCA[1]TCTA[2]TATC[2]

TCTA[n]TCTG[n]TCTA[3]TATC[4]A[1]TCTA[2]TCCA[1]TATC[n]ATC[1]TATC[n]

Reference allele (GRCh38) named with STRNaming 1.2.1

CE29_TCTA[4]TCTG[6]TCTA[3]TATC[4]A[1]TCTA[2]TCCA[1]TATC[12]

Historical bracketing (2016-2023)

[TCTA]4 [TCTG]6 [TCTA]3 ta [TCTA]3 tca [TCTA]2 tccata [TCTA]11

ISFG minimum range (GRCh38)

chr21:19,181,969-19,182,105 (137 bp)

MPS kits covering this locus

PowerSeq 46GY
ForenSeq Signature Prep/Plus and MainstAY
Precision ID GlobalFiler NGS STR Panel v2
IDSeek OmniSTR Global

Allele frequencies at a glance

Most common allele per population group, with its frequency and the sample size, in the capillary electrophoresis data of pop.STR / SP-SMART.

Africa: Allele 30 (0.261, n = 505)
Native American: Allele 28 (0.205, n = 543)
East Asia: Allele 30 (0.324, n = 224)
Central and South Asia: Allele 29 (0.209, n = 194)
Europe: Allele 30 (0.261, n = 2,088)
Middle East: Allele 30 (0.228, n = 160)
Oceania: Allele 29 (0.308, n = 26)

Allele frequencies by population group (pop.STR, CE). Alleles absent from every group are omitted.
Allele	AFR	NAM	EAS	CSA	EUR	MES	OCE
24.3	0.005	0.001	0	0	0	0	0
25.3	0.001	0	0	0	0	0	0
26	0.003	0	0	0.013	0	0	0.019
27	0.026	0.031	0	0.010	0.032	0.016	0
28	0.092	0.205	0.036	0.129	0.155	0.150	0.038
28.2	0	0	0.009	0.003	0	0	0
29	0.247	0.193	0.259	0.209	0.209	0.191	0.308
29.2	0	0.001	0.002	0.003	0.001	0	0
30	0.261	0.202	0.324	0.206	0.261	0.228	0.269
30.2	0.003	0.033	0.018	0.044	0.026	0.028	0.058
30.3	0.001	0	0	0	0.001	0	0
31	0.082	0.066	0.105	0.062	0.073	0.078	0.077
31.2	0.073	0.073	0.063	0.129	0.085	0.134	0.077
32	0.015	0.025	0.027	0.010	0.014	0	0.019
32.1	0	0.001	0	0	0	0	0
32.2	0.055	0.088	0.107	0.126	0.091	0.138	0.058
33	0.003	0.003	0.002	0	0.005	0	0
33.1	0	0.003	0	0	0.001	0	0
33.2	0.028	0.042	0.047	0.044	0.032	0.034	0.038
34	0.027	0.006	0	0	0.002	0	0
34.1	0.001	0	0	0	0	0	0
34.2	0.009	0.004	0.002	0.013	0.001	0	0
35	0.041	0.019	0	0	0.005	0.003	0
36	0.018	0.003	0	0	0.003	0	0
36.1	0.001	0	0	0	0	0	0
37	0.006	0.001	0	0	0	0	0
37.2	0	0	0	0	0	0	0.019
38	0.003	0	0	0	0	0	0
38.2	0	0	0	0	0	0	0.019

Allele frequencies by population group (pop.STR, CE). Alleles absent from every group are omitted.

Variant Alleles

STRbase reports 192 sequence variants across 35 allele designations.

24.2

24.3

25.2

26.2

27.2

28.2

28.3

29.2

29.3

30.2

30.3

31.1

31.2

32.2

33.1

33.2

34.1

34.2

35.2

36.1

Related markers

Other STR markers on chromosome 21

PentaD

Other CODIS core loci

Browse the full STR marker catalog